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HLA-DR Haplotype Details



1-5 



1-5 - Low MSH
 
This haplotype has been statistically correlated with low MSH (melanocyte stimulating hormone). With regard to biotoxin susceptibilty, this haplotype is actually not specifically correlated with increased susceptibility to mold, lyme or other biotoxins1. That being said, Dr. Shoemaker has roughly stated that when MSH falls below 10 any haplotype can function as effectively multisusceptible. Dr. Shoemaker also suggests that MSH falling below 35 can lead to susceptibility to MARCoNS.

MARCoNS (Multiple Antibiotic Resistant Coagulase Negative Staph) is a deep sinus infection that has been said to hinder the progress of treatment.

    © MSH levels can be tested for via LabCorp
    © MARCoNS can be tested for via MicrobiologyDx

Test kits for MARCoNS can be ordered online, and should be administered by an ENT or other medical professional.

Some measures reported as effective at raising low levels of MSH are:

    © Myrrh
    © Forskolin
    © Optimizing the methylation cycle
    © Bee Propolis
    © VIP (Vasoactive Intestinal Polypeptide) Nasal Spray
    © MSH nasal spray
    © High doses of Vitamin C
    © Aspigenin
    © Melanotin (Not to be confused with melatonin)
    © Elderberry
    © Exercise
    © Sunlight
    © Intranasal Ozone
 

Disease Risk
    û Some versions of this haplotype may confer additional risk of Psoriasis2
    û Some verisons of this haplotype may confer additional risk of Rheumatoid Arthritis3
    û Some verisons of this haplotype may confer additional risk of Crohn's Disease4
    û Some verisons of this haplotype may confer additional risk of Ulcerative Colitis5
 

Disease Protection
     Some versions of this haplotype are reported to be protective against Addison's Disease6



References
1.  Surviving Mold, by Ritchie C. Shoemaker
2.  https://www.ncbi.nlm.nih.gov/pubmed/15908298
3.  https://www.ncbi.nlm.nih.gov/pubmed/16126967
4.  https://www.ncbi.nlm.nih.gov/pubmed/15626888
5.  https://www.ncbi.nlm.nih.gov/pubmed/9178675
6.  https://www.ncbi.nlm.nih.gov/m/pubmed/11836294