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HLA-DR Haplotype Details



4-3-53 



4-3-53 - Multisusceptible/Chronic Fatigue
 
With regard to biotoxin susceptibility it is reported that this haplotype is statistically correlated with an increased susceptibility to multiple biotoxins1, including but not limited to:

    © Mold
    © Lyme
    © Ciguatera
    © Pfisteria
    © Dinoflagellates
    © Cyanobacteria derived from blue-green algae
    © Venom from the northern recluse spider
    © Venom from rattlesnakes

It has been suggested that the immune system of those with this haplotype may be unable or less able to properly identify and eliminate these toxins2. Multisusceptible haplotypes have been casually refered to as the 'dreaded' genes on occasion, however first hand experiences of many seem to suggest that those with this haplotype can be treated just as easily as others.

4-3-53 is additionally reported to be statistically correlated with an increased incidence of chronic fatigue syndrome1. Importantly, possessing this haplotype does not mean that you have chronic fatigue syndrome. Rather it means only that you may be at an increased risk of developing chronic fatigue syndrome.
 

Disease Risk
    û Some versions of this haplotype may confer additional risk of Type 1 Diabetes3
    û Some versions of elements of this haplotype may confer additional risk of Rheumatoid Arthritis4
    û Some versions of this haplotype may confer additional risk of Alzheimer's Disease5
    û This haplotype may confer additional risk of Addison's Disease6
 

Disease Protection
     One version of this haplotype is reported to be protective against Type 1 Diabetes3
     Some versions of this haplotype are reported to be protective against Parkinson's Disease7



References
1.  Surviving Mold, by Ritchie C. Shoemaker
2.  The Genetics of Chronic Inflammatory Response Syndrome from Biotoxins, by Dr. David Ou - http://www.drdaveou.com/blog/?p=406
3.  http://diabetes.diabetesjournals.org/content/57/4/1084
4.  https://www.ncbi.nlm.nih.gov/pmc/articles/pmc130004
5.  https://www.ncbi.nlm.nih.gov/pubmed/25651370
6.  https://www.ncbi.nlm.nih.gov/m/pubmed/11836294
7.  https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3824116