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4-3-53 - Multisusceptible/Chronic Fatigue
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With regard to biotoxin susceptibility it is reported that this haplotype is statistically correlated with an increased susceptibility to multiple biotoxins1, including but not limited to:
© Cyanobacteria derived from blue-green algae © Venom from the northern recluse spider © Venom from rattlesnakes
It has been suggested that the immune system of those with this haplotype may be unable or less able to properly identify and eliminate these toxins2. Multisusceptible haplotypes have been casually refered to as the 'dreaded' genes on occasion, however first hand experiences of many seem to suggest that those with this haplotype can be treated just as easily as others.
4-3-53 is additionally reported to be statistically correlated with an increased incidence of chronic fatigue syndrome1. Importantly, possessing this haplotype does not mean that you have chronic fatigue syndrome. Rather it means only that you may be at an increased risk of developing chronic fatigue syndrome.
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Disease Risk
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û Some versions of this haplotype may confer additional risk of Type 1 Diabetes3 û Some versions of elements of this haplotype may confer additional risk of Rheumatoid Arthritis4 û Some versions of this haplotype may confer additional risk of Alzheimer's Disease5 û This haplotype may confer additional risk of Addison's Disease6 û Elements of this haplotype may confer additional risk of Alopecia areata7
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Disease Protection
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✓ One version of this haplotype is reported to be protective against Type 1 Diabetes3 ✓ Some versions of this haplotype are reported to be protective against Parkinson's Disease8
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