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HLA-DR Haplotype Details



15-6-51 



15-6-51 - Post Lyme/MS/Narcolepsy
 
With regard to biotoxin susceptibility it is reported that this haplotype is statistically correlated with an increased incidence of chronic persistent lyme disease1. Importantly, possessing this haplotype does not mean that you have lyme disease. Rather it means only that you may be at an increased risk of developing persistent lyme disease should you initially develop lyme disease by traditional means, such as being bitten by a tick. It has been said that the immune system of those with this haplotype may be unable or less able to properly identify and elimiate toxins associated with lyme disease2, specifically those produced by bacteria of the Borrelia type.

Aspects of this haplotype have also been statistically correlated with an increased incidence of multiple sclerosis3. Again, it is important to understand that possessing this haplotype does not mean that you have multiple sclerosis. Rather it means only that you may be at an increased risk of developing multiple sclerosis. In fact, research has suggested that this increased risk is related to low levels of vitamin d, and that it may be possible to offset the increased risk associated with this haplotype by always ensuring sufficiency4.

Aspects of this haplotype have also been statistically correlated with an increased incidence of narcolepsy5. This does not mean that you have narcolepsy. Rather it means only that you may be at an increased risk of developing narcolepsy.
 

Disease Risk
    û Some versions of this haplotype may confer additional risk of Multiple Sclerosis3
    û Some versions of this haplotype may confer additional risk of Narcolepsy5
    û Some versions of this haplotype may confer additional risk of Parkinson's Disease6
    û Some versions of this haplotype may confer additional risk of Systemic Lupus Erythematosus7
    û Elements of this haplotype may confer additional susceptibility to Aspergillosis8
    û Some versions of this haplotype may confer additional risk of Alzheimer's Disease9
 

Disease Protection
     Some versions of this haplotype are reported to be protective against Type 1 Diabetes10



References
1.  Surviving Mold, by Ritchie C. Shoemaker
2.  The Genetics of Chronic Inflammatory Response Syndrome from Biotoxins, by Dr. David Ou - http://www.drdaveou.com/blog/?p=406
3.  https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3258250
4.  https://www.ncbi.nlm.nih.gov/pubmed/20530326
5.  https://www.ncbi.nlm.nih.gov/pubmed/9456467
6.  https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3824116
7.  http://www.nature.com/ejhg/journal/v15/n8/full/5201827a.html
8.  https://www.ncbi.nlm.nih.gov/pubmed/15709450
9.  https://www.ncbi.nlm.nih.gov/pubmed/25651370
10.  http://diabetes.diabetesjournals.org/content/57/4/1084