HLA-DR Haplotype Details


4-8-53 - Multisusceptible
With regard to biotoxin susceptibility it is reported that this haplotype is statistically correlated with an increased susceptibility to multiple biotoxins1, including but not limited to:

    © Mold
    © Lyme
    © Ciguatera
    © Pfisteria
    © Dinoflagellates
    © Cyanobacteria derived from blue-green algae
    © Venom from the northern recluse spider
    © Venom from rattlesnakes

It has been suggested that the immune system of those with this haplotype may be unable or less able to properly identify and eliminate these toxins2. Multisusceptible haplotypes have been casually refered to as the 'dreaded' genes on occasion, however first hand experiences of many seem to suggest that those with this haplotype can be treated just as easily as others.

Disease Risk
    û Some versions of elements of this haplotype may confer additional risk of Rheumatoid Arthritis3

1.  Surviving Mold, by Ritchie C. Shoemaker
2.  The Genetics of Chronic Inflammatory Response Syndrome from Biotoxins, by Dr. David Ou -