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HLA-DR Haplotype Details



14-5-52B 



14-5-52B - Multisusceptible
 
With regard to biotoxin susceptibility it is reported that this haplotype is statistically correlated with an increased susceptibility to multiple biotoxins1, including but not limited to:

    © Mold
    © Lyme
    © Ciguatera
    © Pfisteria
    © Dinoflagellates
    © Cyanobacteria derived from blue-green algae
    © Venom from the northern recluse spider
    © Venom from rattlesnakes

It has been suggested that the immune system of those with this haplotype may be unable or less able to properly identify and eliminate these toxins2. Multisusceptible haplotypes have been casually refered to as the 'dreaded' genes on occasion, however first hand experiences of many seem to suggest that those with this haplotype can be treated just as easily as others.
 

Disease Protection
     Some versions of this haplotype are reported to be protective against Type 1 Diabetes3
     Some versions of elements of this haplotype are reported to be protective against Systemic Lupus Erythematosus4



References
1.  Surviving Mold, by Ritchie C. Shoemaker
2.  The Genetics of Chronic Inflammatory Response Syndrome from Biotoxins, by Dr. David Ou - http://www.drdaveou.com/blog/?p=406
3.  http://diabetes.diabetesjournals.org/content/57/4/1084
4.  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087792