myhousemakesmesick.com
                        




HLA-DR Haplotype Details



13-3-52A 



13-3-52A - Multisusceptible
 
With regard to biotoxin susceptibility it is reported that this haplotype is statistically correlated with an increased susceptibility to multiple biotoxins1, including but not limited to:

    © Mold
    © Lyme
    © Ciguatera
    © Pfisteria
    © Dinoflagellates
    © Cyanobacteria derived from blue-green algae
    © Venom from the northern recluse spider
    © Venom from rattlesnakes

It has been suggested that the immune system of those with this haplotype may be unable or less able to properly identify and eliminate these toxins2. Multisusceptible haplotypes have been casually refered to as the 'dreaded' genes on occasion, however first hand experiences of many seem to suggest that those with this haplotype can be treated just as easily as others.

13-3-52A was originally classified as benign, however it was reclassified as multisusceptible by Dr. Shoemaker in his book - State of the Art Answers to 500 Questions @ #177.
 

Disease Protection
     Elements of this haplotype are reported to be protective against Systemic Lupus Erythematosus3
     Elements of this haplotype are reported to be protective against Psoriasis3
     Elements of this haplotype are reported to be protective against Rheumatoid Arthritis3
     Elements of this haplotype are reported to be protective against Multiple Sclerosis3
     Research suggests that elements of this haplotype may have a protective effect against many autoimmune diseases3



References
1.  Surviving Mold, by Ritchie C. Shoemaker
2.  The Genetics of Chronic Inflammatory Response Syndrome from Biotoxins, by Dr. David Ou - http://www.drdaveou.com/blog/?p=406
3.  https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4641944